Taking a Look at Oxidative Stress - 1059 Words

Oxidative stress is one of the most important stimuli that initiates CCl4 mediated liver damage. Lipid peroxidation as result of oxidative stress is well known to be involved in the liver injury (Lin et al., 2012). There are a number of studies that has reported the alkynated halogen CCl4 to be widely used as a hepatotoxin to induce liver toxicity in experimental animal models (Weber et al., 2003). Analysis of histopathology revealed that intragastric administration of CCl4 causes damage to the hepatic architecture, as CCl4 is metabolized in the cytochrome P450 mixed oxygenase system found in the endoplasmic reticulum of liver cells and extra hepatic tissues (Fang et al., 2008). CYP2E1 is a major cytochorme found to be involved in carbon-chlorine bond reductive cleavage and biotransformation of CCl4 to trichloromethyl radical (CCl3†¢). These cytochrome systems catalyze many reactions involved in drug metabolism and synthesis of cholesterol and other lipid metabolites both in endogenous substrates, such as ethanol and acetone as well as exogenous substrates which includes carbon tetrachloride (Tang et al., 2013). In the presence of oxygen, CCl3†¢ generates the highly reactive metabolites such as trichloromethyl peroxy (CCl3OO†¢) free radicals which covalently bind to the cellular macromolecules, lipids and polyunsaturated fatty acids in the cellular membrane. Trichloromethyl peroxy (CCl3OO†¢) free radicals react with suitable substrates to complete its electron pair. CCl3OO†¢ isShow MoreRelatedAntioxidants And Its Effects On Health1460 Words   |  6 Pagesthe supplement industry? If you are interested in the answer to any of these questions and more just stick around, I promise your time will be well spent. 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